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This is Omega Centauri, the brightest, largest, and most massive globular in the Milky Way. For example, it has 30 times as many stars (about 10 million) compared to globular cluster M13 shown in the previous image. At about magnitude 4 it is easily visible to the naked eye, but can only be seen from the Earth's southern hemisphere or from low northern latitudes.
The galaxy near the upper left corner of the image is PGC 47340, a spiral about 220 million light years away.